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Chromosome aneuploidy (abnormal chromosome copy number) is a major cause of IVF failure, pregnancy loss and in rare cases, affected live births. Preimplantation genetic testing for aneuploidy (PGT-A), following culture to the blastocyst stage, trophectoderm biopsy, vitrification and testing by next generation sequencing (NGS) based methods for chromosome copy number analysis, is now widely used to identify embryos with normal chromosome copy number (euploid).
In this recorded webinar, Professor Alan Handyside reviews evidence for the effectiveness of PGT-A as an additional tool for embryo selection to improve clinical outcomes, particularly for single embryo transfers. Prof Handyside also considers how to implement PGT-A successfully and reviews prospects for non-invasive testing for aneuploidy (niPGT-A) using spent culture medium.
Topics: genetic testing