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Mini-Series: How Terra Fertility is elevating care and supporting outcomes with EmbryoScope and PGT-A Plus
Data from a recently published clinical study showed a significant increase in detection of euploid/diploid embryos in embryos with confirmed atypical PN using time-lapse technology with EmbryoScope and ploidy detection.
In a study published in the Journal of Assisted Reproduction and Genetics (Girardi et al, 20241), PGT-A by NGS and ploidy testing with SNPs was conducted to explore the correlation between PN status and ploidy configuration in 380 abnormally fertilized (deemed by static observation) euploid zygotes.
Using static observation (no time-lapse), PGT-A Plus’ ploidy analysis found 60% of abnormally fertilized oocytes (AFOs) otherwise not considered for transfer to be euploid/diploid. When EmbryoScope (time-lapse technology) was used to assess PN status, ploidy testing found 20% of AFOs to be euploid/diploid that could be considered for transfer. This shows that both EmbryoScope and ploidy analysis utilized together can increase accuracy in PN status and help identify more viable embryos.
This study also examined the correlation between maternal age and ploidy results and found an increased chance of haploidy and triploidy in those over the age of 35.
Download for a full clinical evidence summary of the data cited in this blog post
Topics: Time-lapse, genetic testing